AI Article Synopsis

  • Glioma is the most common type of malignant brain tumor in adults, and researchers are exploring the use of engineered nanomaterials (ENMs), specifically CuO nanoparticles (NPs), as a potential treatment strategy.* -
  • In experiments with glioma rats and U87MG human glioma cells, CuO NPs showed promising therapeutic effects by reducing inflammation and enhancing the activity of important enzymes while improving memory and spatial recognition.* -
  • Although CuO NPs have potential as a treatment for gliomas, further modifications are needed to enhance their biocompatibility and ensure more targeted delivery in medical applications.*

Article Abstract

Glioma is the most prevalent malignant brain tumor in adults. The development of engineered nanomaterials (ENMs) has led to the emergence of innovative therapeutic strategies for gliomas. Therefore, our aim is to investigate the therapeutic effect of CuO nanoparticles (NPs) on glioma and provide data support for future research. The therapeutic effect of CuO NPs on glioma rats was explored through the detection of inflammatory factors, oxidase, pathological sections, immunofluorescence, neurotransmitter, glioma biomarker proteins and genes, and rat behavioral tests. Additionally, the application prospect of CuO NPs was evaluated by treating U87MG human glioma cell line. In this study, it was found that CuO NPs can alleviate the inflammatory reaction in the hippocampus tissue of glioma rats, promote the production of ·OH and lead to the up-regulation of catalase (CAT) and superoxide dismutase (SOD) enzyme activities. Treatment with CuO NPs also inhibited the expression of matrix metalloproteinase-9 (MMP-9) biomarkers in model rats and glioma cells. Moreover, it enhanced the release of neurotransmitters, which subsequently improved spatial recognition and memory ability of glioma rats. In conclusion, CuO NPs is a potential glioma treatment for ENMs, but still needs modification and modification strategies to improve its biocompatibility and targeted delivery.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455909PMC
http://dx.doi.org/10.1038/s41598-024-74546-7DOI Listing

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