AI Article Synopsis
- Type I interferon (IFN-I) is important for fighting viral infections and managing autoimmune diseases by regulating the expression of interferon-stimulated genes (ISGs).
- This study shows that PCGF3 acts as a suppressor of the antiviral response by inhibiting ISG expression, meaning that less PCGF3 allows for a stronger immune response to IFN-I.
- The research also found that lower levels of PCGF3 in patients with dermatomyositis are linked to higher ISG expression, suggesting that PCGF3 plays a key role in controlling immune responses in disease conditions.
Article Abstract
Type I interferon (IFN-I) plays a crucial role in the antiviral immune response and inflammatory autoimmune diseases by inducing the expression of IFN-stimulated genes (ISGs). Hence, the regulation of ISG expression is fundamental for maintaining immune homeostasis. In this study, we found that PCGF3 negatively regulates the antiviral response by suppressing the expression of ISGs. The deficiency of PCGF3 in innate immune cells results in an augmented expression of ISGs in response to IFN-I stimulation. Mechanistically, PCGF3 is recruited to interferon-stimulated response elements (ISREs) region in an IFN-dependent way, precluding STAT1 from binding to the ISG promoter and diminishing ISRE activity. Additionally, we observed a negative correlation between decreased PCGF3 expression and elevated ISG expression in peripheral blood mononuclear cells (PBMCs) of patients with dermatomyositis (DM). Our findings clarified the epigenetic regulatory role of PCGF3 in inhibiting the excessive expression of ISGs induced by IFN-I under pathological circumstances.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455894 | PMC |
| http://dx.doi.org/10.1038/s41420-024-02194-x | DOI Listing |
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