AI Article Synopsis
- Scientists studied a bacteria called Segatella copri that lives in our gut and affects our health.* -
- They found a tiny RNA called SrcF that is super important for helping the bacteria stick to the gut.* -
- SrcF helps the bacteria use nutrients and is influenced by how other good bacteria in our gut break down certain foods.*
Article Abstract
The bacterium Segatella copri is a prevalent member of the human gut microbiota associated with health and disease states. However, the intrinsic factors that determine its ability to colonize the gut effectively remain largely unknown. By extensive transcriptome mapping of S. copri and examining human-derived samples, we discover a small RNA, which we name Segatella RNA colonization factor (SrcF), and show that SrcF is essential for S. copri gut colonization in gnotobiotic mice. SrcF regulates genes involved in nutrient acquisition, and complex carbohydrates, particularly fructans, control its expression. Furthermore, SrcF expression is strongly influenced by human microbiome composition and by the breakdown of fructans by cohabitating commensals, suggesting that the breakdown of complex carbohydrates mediates interspecies signaling among commensals beyond its established function in generating energy. Together, this study highlights the contribution of a small RNA as a critical regulator in gut colonization.
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| http://dx.doi.org/10.1016/j.chom.2024.09.008 | DOI Listing |
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