LDHB-deficient brain exhibits resistance to ischemic neuronal cell death due to increased vasodilation.

Biochem Biophys Res Commun

Department of Physiology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea. Electronic address:

Published: November 2024

Ischemic stroke triggers a cascade of metabolic and inflammatory events leading to neuronal death, particularly in the hippocampus. Here, we investigate the role of lactate metabolism in ischemic resistance using LDHB-deficient mice, which exhibit impaired lactate utilization. Contrary to expectations of severe neuronal damage due to metabolic defects, LDHB-deficient mice displayed significantly increased neuronal survival following ischemic insult. Magnetic resonance spectroscopy revealed elevated lactate levels in LDHB-deficient brains, which correlated with enhanced vasodilation of the posterior communicating artery (PComA) and increased extracellular PGE levels. These findings suggest that elevated lactate inhibits PGE reabsorption, promoting vasodilation and neuronal protection. Our results highlight lactate's potential role in neuroprotection and its therapeutic promise for ischemic stroke.

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http://dx.doi.org/10.1016/j.bbrc.2024.150766DOI Listing

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