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Exploring the causal relationship between inflammatory cytokines and myasthenia gravis: A two-way Mendelian randomization study.
Cytokine
December 2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. Electronic address:
Background: Based on previous research, it is well-established that myasthenia gravis (MG) is linked to chronic inflammation. However, the exact nature of the relationship between inflammatory factors and the development of MG remains unclear. Consequently, the objective of this study is to explore whether alterations in the levels of inflammatory factors, as influenced by genetic factors, are associated with the occurrence of MG.
View Article and Find Full Text PDFWhite Matter Imaging Phenotypes Mediate the Negative Causality of Mitochondrial DNA Copy Number on Sleep Apnea: A Bidirectional Mendelian Randomization Study and Mediation Analysis.
Nat Sci Sleep
December 2024
Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
Purpose: Sleep apnea (SA), associated with absent neural output, is characterised by recurrent episodes of hypoxemia and repeated arousals during sleep, resulting in decreased sleep quality and various health complications. Mitochondrial DNA copy number (mtDNA-CN), an easily accessible biomarker in blood, reflects mitochondrial function. However, the causal relationship between mtDNA-CN and SA remains unclear.
View Article and Find Full Text PDFSystemic inflammatory regulators and age-related macular degeneration: a bidirectional Mendelian randomization study.
Front Genet
December 2024
Eye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Introduction: We investigated the relationship between systematic regulators of inflammation and the risk of age-related macular degeneration (AMD), both wet and dry forms, by using bidirectional, two-sample Mendelian randomization (MR).
Methods: We performed bidirectional two-sample Mendelian randomization analysis using genome-wide study (GWAS) data for 91 plasma proteins from 14,824 individuals of European descent across 11 study groups. Next, we utilized data from the FinnGen consortium to study AMD using the inverse- variance-weighted approach for Mendelian randomization.
The relationship between inflammatory factors and heart failure: evidence based on bidirectional Mendelian randomization analysis.
Front Cardiovasc Med
December 2024
Cardiology Department, Guang'anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing, China.
Objective: Inflammatory factors play a crucial role in the onset and progression of heart failure. To further explore the causal relationship between inflammatory factors and heart failure, we employed bidirectional Mendelian randomization analysis to investigate the causal links between 91 inflammatory cytokines and heart failure.
Methods: We conducted our study using the bidirectional Mendelian randomization approach.
Discrimination of leaf diseases in Maize/Soybean intercropping system based on hyperspectral imaging.
Front Plant Sci
December 2024
College of Agronomy, College of Mechanical and Electronic Engineering, Shandong Agricultural University, Taian, Shandong, China.
In order to achieve precise discrimination of leaf diseases in the Maize/Soybean intercropping system, i.e. leaf spot disease, rust disease, mixed leaf diseases, this study utilized hyperspectral imaging and deep learning algorithms for the classification of diseased leaves of maize and soybean.
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