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The synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function. | LitMetric

AI Article Synopsis

  • The synaptic vesicle cluster (SVC) is critical for releasing neurotransmitters at chemical synapses and also helps regulate various cofactors involved in exo- and endocytosis.
  • It contains various molecules important for synaptic processes, including cytoskeletal elements and adhesion proteins, and influences the positioning and activity of key organelles like mitochondria.
  • Changes in the size of the SVC may align with alterations in the postsynaptic area, indicating that it plays a central role in synchronizing pre- and postsynaptic functions, which warrants further research into its regulatory mechanisms.

Article Abstract

The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter-loaded vesicles during synaptic activity, at the same time as also controlling the local concentrations of numerous exo- and endocytosis cofactors. In addition, the SVC hosts molecules that participate in other aspects of synaptic function, from cytoskeletal components to adhesion proteins, and affects the location and function of organelles such as mitochondria and the endoplasmic reticulum. We argue here that these features extend the functional involvement of the SVC in synapse formation, signalling and plasticity, as well as synapse stabilization and metabolism. We also propose that changes in the size of the SVC coalesce with changes in the postsynaptic compartment, supporting the interplay between pre- and postsynaptic dynamics. Thereby, the SVC could be seen as an 'all-in-one' regulator of synaptic structure and function, which should be investigated in more detail, to reveal molecular mechanisms that control synaptic function and heterogeneity.

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Source
http://dx.doi.org/10.1113/JP286400DOI Listing

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