AI Article Synopsis
- - The CYP33 enzyme family in the roundworm C. elegans plays key roles in detoxifying harmful substances, regulating bodily processes, and contributing to reproductive health.
- - Research indicates that these enzymes in C. elegans share functions similar to their human counterparts, suggesting they are important for understanding metabolism and disease mechanisms.
- - This review focuses on specific enzymes CYP-33E1 and CYP-33E2 and their human equivalents, shedding light on their significance in various biological processes.
Article Abstract
The CYP33 family in Caenorhabditis elegans is integral to processes like xenobiotic detoxification, eicosanoid regulation, nanotoxicity response and spermatogenesis. Limited research on C. elegans CYP33 suggests its functions are similar to human CYP33, indicating conserved roles in metabolism and disease. This review examines C. elegans CYP33 enzymes, especially CYP-33E1 and CYP-33E2, and their human homologues, focusing on their roles in eicosanoid biosynthesis, xenobiotic metabolism, nanotoxicity and spermatogenesis. Understanding these enzymes enhances insights into cytochrome P450 biology, metabolism and cyp-associated diseases.
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| http://dx.doi.org/10.1002/jat.4707 | DOI Listing |
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