Progress monitoring and action recalibrations are advocated as promising methods for improving road safety, which significantly relates to economic stability and social development. To achieve this, an auditing framework that can evaluate road safety and aid in policymaking is urgently required. To this end, this study developed a systemic decision model that integrates the method based on the removal effects of criteria (MEREC), additive ratio assessment (ARAS), and quantile-based k-means clustering (QBKM), termed MEREC-ARAS-QBKM, with the aim of auditing road safety achievements and providing corresponding policy suggestions with substantial reliability. In particular, the performance of the traditional k-means clustering model was improved by implanting quantiles to determine the initial clustering, which overcomes the uncertainty of k-means clustering owing to the variety of initial cluster centers. Multiple comparisons of empirical results based on a case study of the Asia-Pacific Economic Cooperation (APEC) member economies verified the robustness of the proposed model, demonstrating its applicability, practicability, and reliability in handling real-world multi-criteria decision-making problems in the field of road safety. The empirical findings show that road safety developments among the APEC countries are of class differentiation, suggesting an urgent regional benchmarking. Overall, the proposed methodology empowers decision-makers and policymakers in APEC to swiftly formulate effective action plans, countermeasures, and investment schemes, ultimately contributing to the enhancement of road safety performance and socio-economic benefit across APEC members.
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http://dx.doi.org/10.1038/s41598-024-73069-5 | DOI Listing |
BAY 2413555 is a novel selective and reversible positive allosteric modulator of the type 2 muscarinic acetylcholine (M2) receptor, aimed at enhancing parasympathetic signaling and restoring cardiac autonomic balance for the treatment of heart failure (HF). This study tested the safety, tolerability and pharmacokinetics of this novel therapeutic option. REMOTE-HF was a multicenter, double-blind, randomized, placebo-controlled, phase Ib dose-titration study with two active arms.
View Article and Find Full Text PDFBMC Psychol
December 2024
Department of Behavioral Sciences, Zefat Academic College, Safed, Israel.
Road safety is a critical concern worldwide, impacting individuals, communities, and societies. As mobility increases, so does the risk of accidents and injuries on roads, emphasizing the need for preventive measures. Road safety volunteers contribute significantly to promoting and maintaining road safety, making it important to understand their motivations and resilience sources.
View Article and Find Full Text PDFBMC Med
December 2024
Department of Epidemiology & Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Beijing, 100191, China.
Background: Risk prediction models can identify individuals at high risk of chronic liver disease (CLD), but there is limited evidence on the performance of various models in diverse populations. We aimed to systematically review CLD prediction models, meta-analyze their performance, and externally validate them in 0.5 million Chinese adults in the China Kadoorie Biobank (CKB).
View Article and Find Full Text PDFBMC Med Educ
December 2024
Department of Oral Biology, Sindh Institute of Oral Health Sciences, Jinnah Sindh Medical University, Karachi, Pakistan.
Objectives: Although patient safety has received a lot of emphasis in medicine and nursing, data regarding patient safety perception in dentistry are limited, particularly among dental students. Given the increasing risk of safety hazards, curriculum developers need evidence to guide their implementation in undergraduate studies. This study aimed to determine patient safety culture among undergraduate dental students in Pakistan.
View Article and Find Full Text PDFJ Chromatogr A
December 2024
Environmental & Food Safety Research group of the University of Valencia (SAMA-UV), Desertification Research Centre CIDE (CSIC-UV-GV), Road CV-315 Km 10.7, 46113, Moncada, Valencia, Spain.
Microfibres released from textiles are one of the most common types of microplastics (MPs) found in the environment. Whether they are synthetic or natural, they can undergo degradation in different environmental matrices. This may result in the leaching of a variety of chemicals, mainly textile dyes and additives of high toxicity that need to be regulated.
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