Lignin is the most abundant natural aromatic polymer in the world. Currently, researchers have developed a number of lignin-based composite materials that are widely used in various fields, including industry, agriculture and medicine. Especially in recent years, lignin has attracted great interest as a high-value product for biomedical applications. Due to its antioxidant, antibacterial, adhesive and other properties, lignin is a promising candidate for the development of hydrogel dressings. However, there is no comprehensive overview of the application of lignin-based hydrogel dressings. In this review, lignin-based hydrogel skin dressings were first presented, and the preparation methods of physical and chemical crosslinking in lignin-based hydrogel dressings were discussed. In addition, various functional and environmentally responsive lignin-based hydrogel dressings were primarily reviewed. Finally, the prospects for the development of novel multifunctional lignin-based hydrogel dressings in the future were presented. In conclusion, this review provided a timely and comprehensive summary of the latest advances in the use of lignin as a biomaterial for hydrogel dressings, which would provide valuable guidance for the further development of lignin-based hydrogels.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijbiomac.2024.135786 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
In Situ-Forming, Adhesive, and Antioxidant Chitosan Hydrogels for Accelerated Wound Healing.
Biomacromolecules
January 2025
State Key Laboratory of Separation Membranes and Membrane Processes, School of Material Science and Engineering, Tiangong University, Tianjin 300387, China.
Antioxidant hydrogels that can provide a moist environment and scavenge reactive oxygen species have emerged as highly potential wound dressing materials. In situ-forming and good tissue adhesiveness will make them more desirable, as they can fill the irregular wound defect, stick to the wound, and offer intimate contact with the wound. Herein, a hydrogel dressing combining in situ-forming, good tissue adhesiveness, and excellent antioxidant capabilities was developed by simply conjugating dopamine onto carboxymethyl chitosan.
View Article and Find Full Text PDFAn antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing.
J Nanobiotechnology
January 2025
Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in the microenvironment of wound infection to promote wound healing. In this study, a multifunctional hydrogel drug delivery system (HA@TA-Okra) was constructed through the integration of hyaluronic acid methacrylate (HAMA) matrix with tannic acid (TA) and okra extract. The composition and structural characteristics of HA@TA-Okra system and its unique advantages in the treatment of diverse wounds were systematically evaluated.
View Article and Find Full Text PDFPhotothermal antimicrobial guar gum hydrogel cross-linked by bioactive small molecule lysine for infected wound healing.
Int J Biol Macromol
January 2025
Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430070, China. Electronic address:
The healing of bacteria-infected wounds has long posed a significant clinical challenge. Traditional hydrogel wound dressings often lack self-healing properties and effective antibacterial characteristics, making wound healing difficult. In this study, a bioactive small molecule cross-linking agent 4-FPBA/Lys/4-FPBA (FLF) composed of 4-formylphenylboronic acid (4-FPBA) and lysine (Lys) was utilized to cross-link guar gum (GG) and a tannic acid/iron (TA/Fe) chelate through multiple dynamic bonds, leading to the formation of a novel self-healing hydrogel dressing GG-FLF/TA/Fe.
View Article and Find Full Text PDFTop-down curing to construct self-retaining and moisture-pumping double-layered dressing with enhanced antibacterial, hemostatic, and wound healing performances.
Nanoscale
January 2025
Analytical & Testing Center; West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610064, China.
Continuous microenvironment modulation is an ongoing challenge in wound dressing, which includes excessive exudate absorption, oxygen delivery, bacterial inhibition and angiogenesis. Herein, we developed an construction strategy to fabricate a self-retaining double-layered wound dressing, where the top layer precursor was composed of Ca-containing polyvinyl butyral (PVB) solution dispersed with hydroxypropyl methylcellulose (HPMC) particles, and the bottom one consisted of sodium alginate (Alg) solution blended with Ag-doped mesoporous bioactive glass powders (Ag-MBG). When in use, both precursors were simultaneously squeezed out from the twin nozzles connected to the individual chambers of a twin-chambered syringe, whereby Ca in the top layer rapidly migrated downwards to crosslink Alg in the bottom layer, leading to the formation of an Alg/Ag-MBG (AA) functional hydrogel for filling an irregular wound.
View Article and Find Full Text PDFDual physiological responsive structural color hydrogel particles for wound repair.
Bioact Mater
April 2025
Joint Centre of Translational Medicine, Wenzhou Key Laboratory of Interdiscipline and Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Hydrogel-based patches have demonstrated their values in diabetic wounds repair, particularly those intelligent dressings with continuous repair promoting and monitoring capabilities. Here, we propose a type of dual physiological responsive structural color particles for wound repair. The particles are composed of a hyaluronic acid methacryloyl (HAMA)-sodium alginate (Alg) inverse opal scaffold, filled with oxidized dextran (ODex)/quaternized chitosan (QCS) hydrogel.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!