In this issue of Structure, Cao et al. use X-ray crystallography, biochemical, and genetic studies to define the key role of the Mind bomb-1 ccRING3 domain in triggering Notch signaling, and they demonstrate that ccRING3-mediated dimerization is a key step in ligand activation.
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| http://dx.doi.org/10.1016/j.str.2024.09.009 | DOI Listing |
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