In this issue of Structure, Soeda et al. employed optogenetic tools and demonstrate that an N-terminal truncation of tau and microtubule-binding deficiency lead to the formation of tau condensates, accelerating its fibrillation.
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| http://dx.doi.org/10.1016/j.str.2024.09.004 | DOI Listing |
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Strategic Modulation of Polarity and Viscosity Sensitivity of Bimane Molecular Rotor-Based Fluorophores for Imaging α-Synuclein.
bioRxiv
January 2025
Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, USA.
Molecular rotor-based fluorophores (RBFs) that are target-selective and sensitive to both polarity and viscosity are valuable for diverse biological applications. Here, we have designed next-generation RBFs based on the underexplored bimane fluorophore through either changing in aryl substitution or varying π-linkages between the rotatable electron donors and acceptors to produce red-shifted fluorescence emissions with large Stokes shifts. RBFs exhibit a twisted intramolecular charge transfer mechanism that enables control of polarity and viscosity sensitivity, as well as target selectivity.
View Article and Find Full Text PDFExcess Ub-K48 Induces Neuronal Apoptosis in Alzheimer's Disease.
J Integr Neurosci
December 2024
Department of Human Anatomy, School of Basic Medical Sciences, Wannan Medical College, 241002 Wuhu, Anhui, China.
Background: K48-linked ubiquitin chain (Ub-K48) is a crucial ubiquitin chain implicated in protein degradation within the ubiquitin-proteasome system. However, the precise function and molecular mechanism underlying the role of Ub-K48 in the pathogenesis of Alzheimer's disease (AD) and neuronal cell abnormalities remain unclear. The objective of this study was to examine the function of K48 ubiquitination in the etiology of AD, and its associated mechanism of neuronal apoptosis.
View Article and Find Full Text PDFSynthesis, Trans-Cis Photoisomerization, Fluorescence Decay Studies of Methoxy Ester Functionalized Alkoxy Side Chain Azobenzene Compounds and Their Photoluminescence Dynamics.
J Fluoresc
December 2024
Centre for Nano and Material Sciences, Jain (Deemed-to-be) University, Jain Global Campus, Ramanagaram, Bangalore, 562112, Kanakpuram, Karnataka, India.
In this study, a series of new methoxy ester functionalized core fluorinated, chloro-fluorinated azobenzene derivatives were synthesized. The molecular structures of the azobenzene derivatives (3a-3c and 4a-4c) were confirmed through various analytical methods, with variations in the alkoxy chain length on one end of the aromatic ring. Optical absorption studies of 3a, 3b revealed π-π* transitions around 368-392 nm.
View Article and Find Full Text PDFGSK3β phosphorylation catalyzes the aggregation of tau into Alzheimer's disease-like filaments.
Proc Natl Acad Sci U S A
December 2024
Department for NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen 37077, Germany.
The pathological deposition of proteins is a hallmark of several devastating neurodegenerative diseases. These pathological deposits comprise aggregates of proteins that adopt distinct structures named strains. However, the molecular factors responsible for the formation of distinct aggregate strains are unknown.
View Article and Find Full Text PDFLiquid-liquid phase separation of tau and α-synuclein: A new pathway of overlapping neuropathologies.
Biochem Biophys Res Commun
December 2024
Departamento de Química Biológica Ranwel Caputto, Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC, CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, X5000HUA, Córdoba, Argentina. Electronic address:
Liquid-liquid phase separation (LLPS) is a critical phenomenon that leads to the formation of liquid-like membrane-less organelles within cells. Advances in our understanding of condensates reveal their significant roles in biology and highlight how their dysregulation may contribute to disease. Recent evidence indicates that the high protein concentration in coacervates may lead to abnormal protein aggregation associated with several neurodegenerative diseases.
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