In this issue of Structure, Fan et al. report the structure of the full contactin 2 ectodomain, representing the first for the contactin family. The work reveals six immunoglobulin domains are essential for intercellular interactions, explores differences in proposed contactin 2 homodimerization mechanisms, and provides an updated model for contactin 2 organization on and between cells.
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| http://dx.doi.org/10.1016/j.str.2024.09.003 | DOI Listing |
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