History of symptoms consistent with REM sleep behavior disorder in a population with Parkinson's Disease.

Sleep Med

Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil; Sleep Institute, São Paulo, Brazil. Electronic address:

Published: December 2024

AI Article Synopsis

  • REM Sleep Behavioral Disorder (RBD) is a condition where muscle tone is maintained during REM sleep and is linked to Parkinson's Disease (PD) onset, with this study examining RBD symptoms in 73 PD patients compared to 73 controls.
  • The results showed a significantly higher prevalence of RBD symptoms in PD patients (65%) versus controls (10.09%), with a much higher average RBDSQ score in the PD group (6.03 vs. 2.38).
  • The study suggests that the presence of RBD symptoms is common in PD patients, urging clinicians to assess for these symptoms during evaluations and refer cases to sleep specialists if necessary.

Article Abstract

REM Sleep Behavioral Disorder (RBD) is a parasomnia marked by the maintenance of muscle tone during REM sleep. Evidence has placed RBD as one of the possible prodromal stages of Parkinson's Disease (PD), but data on the proportion of people with PD who have had symptoms of RBD are limited. This study aimed to investigate the history of symptoms compatible with RBD in a population with PD. The sample was composed by 73 patients with clinically diagnosed PD being followed up at a reference outpatient setting, compared to 73 age- and sex-matched individuals with no PD. The evaluation of symptoms compatible with RBD was performed using the Brazilian version of the RBD Screening Questionnaire (RBDSQ). The prevalence of symptoms compatible with RBD was 65 % for PD and 10.09 % for controls. The RBDSQ score was significantly higher in the PD group (6.03 ± 0.35) in comparison to the control group (2.38 ± 0.23). The odds ratio for presenting previous RBD-compatible symptoms was 12.09 in favor of positive PD cases. PD diagnosis has the following diagnostic properties in relation to presenting RBD symptoms: sensitivity of 0.65, specificity of 0.86, positive predictive value of 0.82 and negative predictive value of 0.71. In conclusion, the proportion of PD patients showing RBD symptoms is high, corroborating the expected neuroprogression of the disease on a case-control design comprising outpatient PD cases. Clinical practitioners should include evaluations of RBD-compatible symptoms during the PD assessment and, if positive, forward to a sleep specialist.

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Source
http://dx.doi.org/10.1016/j.sleep.2024.09.042DOI Listing

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