AI Article Synopsis

  • Phosphorus Magnetic Resonance Spectroscopy (P MRS) is a noninvasive technique used to assess energy metabolism, but high magnetic fields often create sensitivity and spatial issues; the novel fast double-angle method (fDAM) is proposed to address these challenges.
  • The fDAM method utilizes advanced 3D acquisitions and frequency-selective pulses to efficiently map phosphocreatine signals at 7T, showing promising results in both phantom studies and human brain/muscle applications.
  • The study findings demonstrate that fDAM provides a strong correlation with traditional methods while significantly reducing mapping time and improving coverage, suggesting its potential for quick P MRSI applications in future research.

Article Abstract

Purpose: Phosphorus MRS (P MRS) enables noninvasive assessment of energy metabolism, yet its application is hindered by sensitivity limitations. To overcome this, often high magnetic fields are used, leading to challenges such as spatial inhomogeneity and therefore the need for accurate flip-angle determination in accelerated acquisitions with short TRs. In response to these challenges, we propose a novel short TR and look-up table-based double-angle method for fast 3D P mapping (fDAM).

Methods: Our method incorporates 3D weighted stack-of-spiral gradient-echo acquisitions and a frequency-selective pulse to enable efficient mapping based on the phosphocreatine signal at 7 T. Protocols were optimized using simulations and validated through phantom experiments. The method was validated in the human brain using a P 1Ch-trasmit/32Ch-receive coil and skeletal muscle using a birdcage H/P volume coil.

Results: The results of fDAM were compared with the classical DAM. A good correlation (r = 0.95) was obtained between the two maps. A 3D P mapping in the human calf muscle was achieved in about 10:50 min using a birdcage volume coil, with a 20% extended coverage (number of voxels with SNR > 3) relative to that of the classical DAM (24 min). fDAM also enabled the first full-brain coverage P 3D mapping in approximately 10:15 min using a 1Ch-transmit/32Ch-receive coil.

Conclusion: fDAM is an efficient method for P 3D mapping, showing promise for future applications in rapid P MRSI.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604843PMC
http://dx.doi.org/10.1002/mrm.30321DOI Listing

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