Gold nanorods (GNRs) are unique nanoparticles with easily functionalized surfaces, multiple synthesis methods, photothermal conversion, and surface plasmon resonance effects. These properties make GNRs suitable for various biological applications. However, a rapid synthesis of GNRs using less toxic chemicals is needed. The photochemical method is a viable option that can synthesize GNRs quickly while using fewer chemicals. A photochemical method is reported for the synthesis of GNRs using Irgacure-2959 as a reducing agent. This method could be used to synthesize GNRs with a rod-like shape within 30 min. Additionally, GNRs were coated with sericin (GNRs-SC) to further reduce their toxicity in human dermal fibroblast adult cells. Low-level near-infrared (NIR) light was applied to enhance the photothermal therapy of both GNRs and GNRs-SC. The results showed that GNRs and GNRs-SC under low-level NIR light have enhanced antibacterial activity against and , as well as antibiofilm activity against . Furthermore, GNRs-SC showed good biocompatibility with antibacterial and antibiofilm activities. These results indicate that GNRs-SC are good candidates for various biological applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.langmuir.4c02984 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synthesis and Self-Assembly of Monodisperse Graphene Nanoribbons: Access to Submicron Architectures with Long-Range Order and Uniform Orientation.
ACS Nano
January 2025
Department of Chemistry, University of Chicago, Chicago, Illinois 60637, United States.
Fabricating organic semiconducting materials into large-scale, well-organized architectures is critical for building high-performance molecular electronics. While graphene nanoribbons (GNRs) hold enormous promise for various device applications, their assembly into a well-structured monolayer or multilayer architecture poses a substantial challenge. Here, we report the preparation of length-defined monodisperse GNRs via the integrated iterative binomial synthesis (IIBS) strategy and their self-assembly into submicrometer architectures with long-range order, uniform orientation, as well as regular layers.
View Article and Find Full Text PDFGold Nanorod-Coated Hydrogel Brush Valves in Macroporous Silicon Membranes for NIR-Driven Localized Chemical Modulation.
Gels
January 2025
Department of Electrical Engineering, The City College of New York, 160 Convent Avenue, New York, NY 10031, USA.
A two-dimensional array of microfluidic ports with remote-controlled valve actuation is of great interest for applications involving localized chemical stimulation. Herein, a macroporous silicon-based platform where each pore contains an independently controllable valve made from poly(N-isopropylacrylamide) (PNIPAM) brushes is proposed. These valves are coated with silica-encapsulated gold nanorods (GNRs) for NIR-actuated switching capability.
View Article and Find Full Text PDFTiC MXene/GNRs for synergistically highly enhanced sensitivity of optical fiber SPR acetylcholine biosensors via an electrostatic layer-by-layer assembly method.
Biosens Bioelectron
January 2025
Innovation Center of Functional Genomics and Molecular Diagnostics Technology of Gansu Province, Lanzhou, China.
Improving the sensitivity of biosensor has always the major challenge to measure lower detection concentration of biological samples. In this paper, a novel optical fiber surface plasmon resonance (SPR) biosensor based on TiC MXene/GNRs synergistically highly enhanced sensitivity was proposed. The TiC MXene and GNRs were coated on the optical fiber sensing probe by the electrostatic layer-by-layer (ELBL) assembly method.
View Article and Find Full Text PDFFacile Synthesis of Monodisperse Gold Nanorods, Gold Nanobipyramids and Gold Nanocups with Different Coatings and Evaluation of Their Cellular Cytotoxicity.
Curr Drug Deliv
January 2025
School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Article Synopsis
- The study highlights the rising importance of assessing the cytotoxicity of gold nanoparticles (GNPs) in biomedical applications.
- Researchers synthesized three types of GNPs—gold nanorods (GNRs), gold nanobipyramids (GNBPs), and gold nanocups (GNCs)—using a specific method and measured their sizes.
- The experiments showed that the cytotoxic effects of GNPs varied based on their shape and surface coating, with CTAB-coated GNPs being more harmful than PEG-coated ones, indicating that these factors significantly influence GNP behavior in cells.
Dissecting the anti-pancreatic cancer mechanism of gold nanorods mediate photothermal therapy through quantitative proteomics analysis.
Biochem Biophys Res Commun
February 2025
Department of Oncology, The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian, Liaoning, 110006, China. Electronic address:
Gold nanorods (GNRs) mediated photothermal therapy (PTT) represents a promising technique for cancer treatment, utilizing GNRs in conjunction with near-infrared (NIR) laser irradiation to convert energy into heat. In the present study, we employed PTT to induce apoptosis in pancreatic cancer cells and investigated its underlying mechanisms through quantitative proteomics analysis. Initially, we established that temperatures ranging from 47 to 51°C significantly enhance cellular apoptosis without inducing necrosis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!