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Genomic epidemiology of Plasmodium knowlesi reveals putative genetic drivers of adaptation in Malaysia.
PLoS Negl Trop Dis
March 2025
Global and Tropical Health, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia.
Sabah, Malaysia, has amongst the highest burden of human Plasmodium knowlesi infection in the world, associated with increasing encroachment on the parasite's macaque host habitat. However, the genomic make-up of P. knowlesi in Sabah was previously poorly understood.
View Article and Find Full Text PDFData Obfuscation Through Latent Space Projection for Privacy-Preserving AI Governance: Case Studies in Medical Diagnosis and Finance Fraud Detection.
JMIRx Med
March 2025
Stelmith, LLC, 2333 Aberdeen Pl, Carollton, TX, 75007, United States, 1 9459001314.
Background: The increasing integration of artificial intelligence (AI) systems into critical societal sectors has created an urgent demand for robust privacy-preserving methods. Traditional approaches such as differential privacy and homomorphic encryption often struggle to maintain an effective balance between protecting sensitive information and preserving data utility for AI applications. This challenge has become particularly acute as organizations must comply with evolving AI governance frameworks while maintaining the effectiveness of their AI systems.
View Article and Find Full Text PDFThe mechanisms of resistance, epidemiological characteristics, and molecular evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae.
Lab Med
March 2025
Department of Clinical Laboratory, People's Hospital of Dayi County, Chengdu Sichuan, China.
Introduction: Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is a highly pathogenic, drug-resistant, and transmissible "superbug" that causes infections in hospitals and communities. Because of the lack of effective antimicrobial treatment options, morbidity and mortality from CR-hvKP infections have increased dramatically, and outbreaks and the rapid spread of CR-hvKP in hospitals have become a major global public health challenge.
Methods: The mechanisms of molecular evolution in CR-hvKP include the acquisition of a hypervirulent plasmid encoding a virulence gene by carbapenemase-producing K pneumoniae, the horizontal transfer of plasmids carrying carbapenem resistance genes to hvKP, and the acquisition of fusion plasmids carrying both carbapenem resistance genes and hypervirulent genes by classic K pneumoniae.
Preserving the Biologically Coherent Generic Concept of , 'Plant Destroyer'.
Phytopathology
March 2025
Mendel University in Brno, Phytophthora Research Centre, Department of Forest Protection and Wildlife Management, Faculty of Forestry and Wood Technology, Zemědělská 3, 613 00 Brno, Brno, Czech Republic, 613 00;
is a long-established, well known and globally important genus of plant pathogens. Phylogenetic evidence has shown that the biologically distinct, obligate biotrophic downy mildews evolved from at least twice. Since, cladistically, this renders 'paraphyletic', it has been proposed that evolutionary clades be split into multiple genera (Runge et al.
View Article and Find Full Text PDFA Comprehensive Review on Cellulose Nanofibers, Nanomaterials, and Composites: Manufacturing, Properties, and Applications.
Nanomaterials (Basel)
February 2025
Department of Mechanical Engineering, University of Nevada-Reno, Reno, NV 89557, USA.
Cellulose nanofibers (CNFs), cellulose nanomaterials (CNMs), and cellulose-based composites represent a convergence of material science, sustainability, and advanced engineering, paving the way for innovative and eco-friendly materials. This paper presents a comprehensive review of these materials, encompassing their extraction, preparation methods, properties, applications, and future directions. The manufacturing of CNFs and CNMs leverages diverse techniques-chemical, mechanical, and enzymatic-with each offering distinct advantages in tailoring material characteristics to meet specific needs.
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