Enhanced lymphangiogenesis in the left lateral segment of a biopsied liver during portoenterostomy for biliary atresia.

Pediatr Surg Int

Department of Pediatric Surgery, Research Field in Medical and Health Sciences, Medical and Dental Area, Research and Education Assembly, Kagoshima University, Kagoshima, Japan.

Published: October 2024

AI Article Synopsis

  • The study explores how the branching of the portal vein and lymphatic vessels contribute to liver atrophy in biliary atresia (BA).
  • Liver biopsy samples from ten BA patients were analyzed using specific staining techniques to compare the left lateral segment (LLS) and right anterior segment (RAS) of the liver.
  • Findings indicated that the LLS had higher fibrosis scores and showed a significant correlation between lymphatic vessel numbers and both fibrosis and age at surgery, suggesting a link between lymphatic growth and liver damage in BA.

Article Abstract

Purpose: We investigate the histopathology of the portal vein branches and lymphatic vessels to elucidate the mechanism of atrophy of the left lateral segment (LLS) of the liver in biliary atresia (BA).

Methods: LLS and right anterior segment (RAS) liver biopsy samples obtained during Kasai portoenterostomy (KPE) from ten consecutive patients with BA underwent histopathological investigation of the portal vein and lymphatic vessels using double chromogenic immunostaining for CD31/D2-40 and the hepatitis-like findings (HLF) score. Each parameter and clinical data were compared between prognostic groups.

Results: HLF scores in the LLS were always higher than those in the RAS. There was no difference in portal vein and lymphatic vascular morphology, whereas the number of lymphatic vessels was correlated with the fibrotic area of all specimen areas. Left-to-right ratio of the number of lymphatic vessels was correlated with the age at KPE (r = 0.784, p = 0.007) and the pre-KPE CRP value (r = 0.723, p = 0.018).

Conclusions: Lymphangiogenesis on the LLS compared to the RAS was significantly correlated with the degree of fibrosis and the age at KPE. Further investigation is warranted to clarify the causes of LLS atrophy and lymphangiogenesis relevant to immune dysregulation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452420PMC
http://dx.doi.org/10.1007/s00383-024-05845-3DOI Listing

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