AI Article Synopsis
- - The peritoneal cancer index helps evaluate the extent of peritoneal disease before surgery.
- - Current imaging methods like 18 F-FDG PET/CT are better than CT but still underestimate the disease because of high background activity in the body.
- - A new imaging technique using 68 Ga-trivehexin targets cancer integrins, showing less background activity and potentially providing a more accurate assessment of advanced epithelial ovarian cancer.
Article Abstract
Peritoneal cancer index is an integral parameter for preoperative assessment of peritoneal disease. Current imaging modalities including 18 F-FDG PET/CT, though superior to CT, underestimate the disease extent, mainly due to its high physiological background activity. Novel "cancer integrin" targeting imaging with 68 Ga-trivehexin demonstrates limited physiological activity in the abdomen with superior target-to-background ratio than 18 F-FDG PET/CT. Thus, we describe the first case demonstrating potential utility of novel "cancer integrin" αvβ6 imaging agent 68 Ga-trivehexin for assessment of disease burden in advanced epithelial ovarian cancer.
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| http://dx.doi.org/10.1097/RLU.0000000000005485 | DOI Listing |
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