Lead migration is a common complication of spinal cord stimulation, although anterior migration is rare. While early studies suggested that anterior stimulation may produce analgesic effects, it is thought to be poorly tolerated due to abnormal paresthesia and muscle contractions due to its proximity to the corticospinal tract. This case report presents a unique case of sustained pain relief despite anterior lead migration, which suggests that anterior column stimulation may hold clinical significance for pain management. Further studies are needed to explore its analgesic mechanisms and potential therapeutic application. Strategies to prevent lead migration, particularly in the early postoperative period, are also crucial for optimizing outcomes.
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http://dx.doi.org/10.1080/17581869.2024.2407283 | DOI Listing |
Microorganisms
November 2024
School of Earth System Science, Tianjin University, Tianjin 300072, China.
Contained arsenic (As) and unsafe brackish groundwater irrigation can lead to serious As pollution and increase the ecological risk in cultivated soils. However, little is known about how Fe oxides and microbes affect As migration during soil irrigation processes involving arsenic-contaminated brackish groundwater. In this study, the samples (porewater and soil) were collected through the dynamic soil column experiments to explore the As migration process and its effect factors during soil irrigation.
View Article and Find Full Text PDFPharmaceuticals (Basel)
December 2024
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.
The protein kinases CLK and ROCK play key roles in cell growth and migration, respectively, and are potential anticancer targets. ROCK inhibitors have been approved by the FDA for various diseases and CLK inhibitors are currently being trialed in the clinic as anticancer agents. Compounds with polypharmacology are desired, especially in oncology, due to the potential for high efficacy as well as addressing resistance issues.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA.
Besides various infectious and inflammatory complications, recent studies also indicated the significance of NLRP3 inflammasome in cancer progression and therapy. NLRP3-mediated immune response and pyroptosis could be helpful or harmful in the progression of cancer, and also depend on the nature of the tumor microenvironment. The activation of NLRP3 inflammasome could increase immune surveillance and the efficacy of immunotherapy.
View Article and Find Full Text PDFLife (Basel)
December 2024
First Department of Critical Care Medicine, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 106 76 Athens, Greece.
Aquaporins (AQPs) are membrane proteins facilitating water and other small solutes to be transported across cell membranes. They are crucial in maintaining cellular homeostasis by regulating water permeability in various tissues. Moreover, they regulate cell migration, signaling pathways, inflammation, tumor growth, and metastasis.
View Article and Find Full Text PDFBiomedicines
December 2024
Departamento de Ciência Básica, Instituto de Saúde de Nova Fribrugo, Universidade Federal Fluminense, Nova Friburgo 28625-650, RJ, Brazil.
Pyruvate kinase M2, a central regulator of cancer cell metabolism, has garnered significant attention as a promising target for disrupting the metabolic adaptability of tumor cells. This study explores the potential of the Mannich base derived from lawsone () to interfere with PKM2 enzymatic activity both in vitro and in silico. The antiproliferative potential of was tested using MTT assay in various cell lines, including SCC-9, Hep-G2, HT-29, B16-F10, and normal human gingival fibroblast (HGF).
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