AI Article Synopsis
- Bacterial infections are a major global health issue, worsened by the rise of drug-resistant bacteria, making it essential to explore new treatments from marine sources.
- Marine-derived fungi are highlighted as a promising source of unique bioactive compounds that could combat harmful bacteria.
- This study reviews 337 natural products, including 145 new compounds, classified into five categories, showcasing their potential in developing innovative antimicrobial agents.
Article Abstract
Bacterial infections pose a significant clinical burden on global health. The growing incidence of drug-resistant pathogens highlights the critical necessity to identify and isolate bioactive compounds from marine resources. Marine-derived fungi could provide novel lead compounds against pathogenic bacteria. Due to the particularity of the marine environment, species derived from marine sources have proven to be potent producers of bioactive secondary metabolites and have played a considerable role in advancing drug development. This study reviews the structural diversity and activities against pathogenic bacteria of secondary metabolites isolated from marine-derived species over the past 14 years (January 2010-June 2024), and 337 natural products (including 145 new compounds) were described. The structures were divided into five major categories-terpenoids, nitrogen-containing compounds, polyketides, steroids, and other classes. These antimicrobial metabolites will offer lead compounds to the development and innovation of antimicrobial agents.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446753 | PMC |
| http://dx.doi.org/10.3389/fmicb.2024.1464135 | DOI Listing |
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