AI Article Synopsis
- - This study assessed the effects of the pain medications phenyramidol and diclofenac on bone healing in a rat model of femur fractures, focusing on radiological, histological, and biomechanical evaluations over time.
- - A total of 72 male rats were divided into groups receiving different treatments (phenyramidol, diclofenac, both, or none) and were examined at various postoperative intervals (15, 30, 45 days) for their healing progress.
- - The findings indicated that both medications alone hindered fracture healing, but their combined use was somewhat less detrimental. While there were some differences in healing outcomes among the groups, overall, histological assessments showed no significant improvement in bone healing with either medication
Article Abstract
Background: Fracture healing or nonunion refers to a process in which many factors interact. In this study, we aimed to evaluate the radiological, histological, and biomechanical effects of phenyramidol and diclofenac, which are frequently used to treat post-fracture ture pain worldwide, on fracture healing and nonunion in a rat femur fracture model.
Methods: In this study, 72 male Wistar-Albino rats aged 2-3 months and weighing 250 ± 30 g were divided into 4 main groups. The rats were divided into 12 subgroups according to the early, middle, and late periods. A fracture model was created in rat femurs, and surgical fixation was performed. Postoperative analgesic treatment protocols included phenyramidol, diclofenac, phenyramidol + diclofenac, and the control group. The rats were sacrificed on the fifteenth, thirtieth, and forty-fifth days and were evaluated radiologically, histopathologically, and biomechanically.
Results: Scoring was conducted independently by 2 orthopedists not involved in the study. When the results were analyzed statistically, no statistically significant difference was observed between the fifteenth and thirtieth day radiology score values of the control, diclofenac, phenyramidol, and Phenyramidol + diclofenac groups ( > 0.05), but there was a statistically significant difference ( < 0.05) between the forty-fifth day radiology score values of the control, diclofenac, phenyramidol, and phenyramidol + diclofenac groups.
Conclusions: Our study shows that the use of diclofenac or phenyramidol alone negatively affects postoperative fracture healing. However, this effect was less pronounced in the combined treatment group. Histologic examination revealed that neither treatment had a significant effect on healing. There were statistical differences in biomechanical and radiologic properties between the phenyramidol and diclofenac groups; in particular, the diclofenac group had lower biomechanical properties.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444952 | PMC |
| http://dx.doi.org/10.4055/cios24056 | DOI Listing |
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