Background: Chronic dystonia, characterised by sustained muscle contractions and abnormal postures, poses clinical challenges, especially when associated with antipsychotic medication use.
Aim: To delineate the demographic and clinical profiles of adults with dystonia and examine the association with antipsychotic medication.
Setting: Botulinum Toxin Clinic at Tygerberg Hospital, Cape Town, South Africa.
Methods: We conducted a retrospective cohort study of adult patients seen at the Botulinum Toxin Clinic between January 2018 and June 2022.
Results: Of the 119 patients studied, those assessed with antipsychotic-induced dystonia (32.69%) presented at a younger age ( < 0.001), were more likely female ( = 0.04), received higher average dose of Botulinum toxin ( < 0.001), and incurred a higher estimated Botulinum toxin treatment cost ( = 0.01) compared to those with primary dystonia. Logistic regression identified age and Botulinum toxin dose as factors associated with psychotropic-related dystonia ( = 0.005 and = 0.012, respectively).
Conclusion: Clinical and demographic factors are associated with dystonia in adults taking antipsychotic medication. These patients generally manifested symptoms at an earlier age, had a higher male prevalence, and required prolonged treatment with Botulinum toxin, leading to increased costs. In those assessed with antipsychotic-induced dystonia, a comorbid diagnosis of a mood disorder was more common than that of a psychotic disorder.
Contribution: By identifying the demographic and clinical profile of individuals with dystonia because of antipsychotic medication, this study provides a basis for preventative strategies and enhanced patient care.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447561 | PMC |
http://dx.doi.org/10.4102/sajpsychiatry.v30i0.2270 | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!