AI Article Synopsis
- This study looked at different treatments for patients with blood cancers who had a transplant, comparing two specific methods: PTCy alone and PTCy with a lower dose of ATG.
- Researchers matched patients from these groups to ensure the comparisons were fair and accurate.
- Results showed that the PTCy group had better outcomes, including quicker recovery of important blood cells called neutrophils and platelets, which are crucial for fighting infections and clotting.
Article Abstract
This study aimed to demonstrate the clinical outcomes of granulocyte colony-stimulating factor (G-CSF)/antithymocyte globulin (ATG), posttransplantation cyclophosphamide (PTCy) and PTCy combined with lowdose ATG (PTCy with ATGlow)-based haploidentical transplantation protocols in patients with haematologic malignancies. The comparisons were conducted via propensity score matching (PSM) analysis to balance the basic characteristics among different groups and were based on the transplantation data reported to the Chinese Bone Marrow Transplantation Registry Group (CBMTRG) from January 2020 to December 2022. For each patient in the PTCy or PTCy with ATGlow group, patients (at a 1:2 ratio) from the GCSF/ ATG group were selected. In total, the PTCy group (n=122) was matched with G-CSF/ATG Group 1 (n=230), and the PTCy+ATGlow group (n=123) was matched with G-CSF/ATG Group 2 (n=226). Compared with those in the PTCy group, the incidences of 28-day neutrophil engraftment (P=0.005), 100- day platelet engraftment (P=0.002), median time to neutrophil engraftment (P.
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| http://dx.doi.org/10.3324/haematol.2024.286040 | DOI Listing |
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