AI Article Synopsis
- The study aimed to investigate the relationship between the frequency of generalized spike-waves (GSWs) and different types of idiopathic generalized epilepsy (IGE) as well as treatment outcomes.
- A total of 583 patients from the Shiraz University epilepsy center were analyzed across four IGE syndromes, finding that GSWs were present in all types but did not correlate significantly with either syndrome classification or response to treatment.
- Overall, while GSWs are common in IGEs, their presence and frequency do not provide significant insights into diagnosis or treatment efficacy.
Article Abstract
Objectives: We hypothesized that the frequency (in Hertz) of generalized spike-waves (GSWs) in patients with idiopathic generalized epilepsy (IGE) has associations with the syndromic diagnosis as well as with the prognosis of patients (their response to medical treatment).
Methods: This was a retrospective study of a prospectively developed database. All patients with a diagnosis of IGE were studied at the epilepsy center at Shiraz University of Medical Sciences, Shiraz, Iran, from 2008 until 2022. Patients were classified into four IGE syndromes: childhood absence epilepsy; juvenile absence epilepsy; juvenile myoclonic epilepsy; and generalized tonic-clonic seizures alone.
Results: Five hundred and eighty-three patients were studied. GSWs were commonly observed in all four syndromes of IGE. Frequency of GSW (in Hertz) did not have a significant association with the syndromic diagnosis of the patients (p = .179). The presence of GSW did not have a significant association with the seizure outcome (becoming seizure free or not) of the patients (p = .416). Frequency of GSW did not have a significant association with the seizure outcome of the patients either (p = .574).
Conclusion: GSWs are the hallmark electroencephalographic footprints of idiopathic generalized epilepsies; however, neither their presence nor their frequency has practical associations with the syndromic diagnosis of IGEs or their outcome (response to treatment).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450249 | PMC |
| http://dx.doi.org/10.1002/brb3.70023 | DOI Listing |
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