AI Article Synopsis
- The ethanol extract from Clausena excavata roots yielded two new coumarins (clauexcatin A and B) and trans/cis isomers of clauexcatin C, in addition to thirty known compounds, including one (compound 33) never before isolated from this genus.
- The structures of these compounds were determined using physicochemical properties and spectroscopic analysis.
- Anti-neuroinflammatory effects were evaluated on BV-2 microglial cells, with certain compounds showing significantly greater inhibition of nitric oxide release compared to the positive control minocycline.
Article Abstract
The ethanol extract of the roots of Clausena excavata gave two previously undescribed coumarins, clauexcatin A (1) and clauexcatin B (2), as well as a pair of new isomers, trans/cis-clauexcatin C (3a, 3b), along with thirty known compounds. Among these, compound 33 was isolated from this genus for the first time. The structures of these compounds were elucidated based on their physicochemical properties and spectroscopic data. The anti-neuroinflammatory activities were assessed using LPS-activated BV-2 microglial cells. Compounds 6, 8, 17, 24, 29, and 30 exhibited significant inhibition of nitric oxide release in a dose-dependent manner, with their inhibitory effects being 1.2 to 10.9 times greater than that of the positive control (minocycline).
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| http://dx.doi.org/10.1002/cbdv.202401653 | DOI Listing |
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