AI Article Synopsis
- Improving the tumor immune microenvironment is crucial for better cancer treatment results.
- Researchers found that iron chelation boosts type I interferon production, which helps activate NK cells and improves their ability to target tumors.
- Additionally, combining iron chelation with the chemotherapy drug cisplatin shows promising effects in reducing metastatic ovarian cancer in mouse models.
Article Abstract
Ameliorating the tumor immune microenvironment is a key strategy to improve the therapeutic outcomes of patients with cancer. Sandoval and colleagues demonstrate that iron chelation enhances type I IFN production, promotes NK cell tumor trafficking and activation, and synergizes with chemotherapy drug cisplatin to reduce metastatic ovarian cancer progression in murine models. See related article by Sandoval et al., p. 1901.
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| http://dx.doi.org/10.1158/2159-8290.CD-24-1012 | DOI Listing |
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