Baker and colleagues developed a new algorithm called "Gain Route Identification and Timing In Cancer" (GRITIC) to uncover the path of chromosomal evolution in a tumor, particularly in the context of whole-genome duplication. Their approach found that tumors with genome doubling frequently take an indirect path from one copy number state to another. In addition, the timing of genome doubling within a tumor's evolution impacts its consequences on downstream chromosomal instability. See related article by Baker et al., p. 1810.
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| http://dx.doi.org/10.1158/2159-8290.CD-24-1017 | DOI Listing |
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