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http://dx.doi.org/10.4103/aian.aian_571_24 | DOI Listing |
Int Immunopharmacol
January 2025
Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:
This study aimed to elucidate the protective roles of Immune Response Gene-1 (IRG1) and exogenous itaconate in murine models of hepatic fibrosis and to delineate the underlying mechanistic pathways using both wild-type and IRG1-deficient (IRG1) mice. Primary murine stellate cells (mHSC) and bone marrow-derived macrophages (BMDM) were isolated and cocultured. Hepatocellular fibrosis was induced in vitro using Transforming Growth Factor-beta (TGF-β) to evaluate the protective efficacy of IRG1/itaconate.
View Article and Find Full Text PDFAnn Indian Acad Neurol
November 2024
Department of Dermatology, Kaya Clinics, Jubilee Hills, Hyderabad, Telangana, India.
Free Radic Biol Med
October 2024
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Electronic address:
Long non-coding RNAs play a key role in silicosis, a fatal fibrotic lung disease, and there is an urgent need to develop new treatment targets. Long intergenic non-protein-coding RNA 3047 (LINC03047) is associated with cancer, but its role and mechanism in the progression of silicosis require further elucidation. This study investigated the function of LINC03047 in the epithelial-mesenchymal transition (EMT) during silicosis progression.
View Article and Find Full Text PDFNoro Psikiyatr Ars
February 2024
Selçuk University Medical Faculty, Departments of Neurology and Physiology, Konya, Turkey.
Introduction: Metabolic dysfunctions are critical in the pathology of Alzheimer's disease. Impaired zinc homeostasis, in particular, is a significant issue in this disease that has yet to be explained. Gene expression of ZIP14 in brain tissue has been previously reported.
View Article and Find Full Text PDFInt J Mol Sci
January 2024
College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, Yangzhou 225009, China.
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