AI Article Synopsis
- - Bipolar disorder (BD) increases the risk of neurodegenerative diseases, including dementia and Parkinson's disease (PD), but the influence of BD medications on this risk is still unclear.
- - A study involving over 500,000 participants found that those with BD had a significantly higher risk for developing dementia (2.52 times) and PD (2.88 times) compared to those without BD.
- - It's suggested that about two-thirds of the relationship between BD and these neurodegenerative diseases might be due to medications used to treat BD, indicating a need for further research on this topic.
Article Abstract
Bipolar disorder (BD) is linked to an increased risk of neurodegenerative diseases such as dementia and Parkinson disease (PD), yet several uncertainties still remain and the extent to which the associations could be explained by BD-related medications (antipsychotics, lithium, and antiepileptics) was unknown. This study included 501,233 UK Biobank participants (mean [standard deviation] age, 56.5 [8.10] years; 54.4% women), free of dementia and PD at baseline. After a median 13.8 year follow-up, 9422 cases of dementia and 3457 PD cases were identified. Participants with BD had a significantly higher risk of dementia (adjusted hazard ratio [HR] 2.52, 95% CI 2.00-3.19) and PD (adjusted HR 2.88, 95% CI 2.03-4.08). Findings suggest that up to two-thirds of the association of neurodegenerative diseases with BD may be mediated by BD-related medications. Further research is needed to confirm these findings and explore the underlying mechanisms.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450157 | PMC |
| http://dx.doi.org/10.1038/s41531-024-00794-z | DOI Listing |
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