species (>1700) are widespread causative agents of coccidiosis in animals. Most species reproduce in the intestinal epithelial cells of distinct hosts. infects the cecum of for its asexual and sexual reproduction. Parasite infection results in diarrhea and weight loss, and pathogenicity depends on the dose of infection as well as the age and immune status of the host. The short, monoxenous life cycle of in a model host (., mouse) enables research on poorly studied coccidian stages. Several parasite-specific biological phenomena, such as schizogony, gametogenesis, oocyst formation, sporulation. and mucosal immunity can be examined in significant detail. The –mouse model is valuable for deciphering the network design principles and molecular determinants of intracellular parasitism, and thereby developing novel antiparasitic intervention strategies against poultry and livestock coccidiosis caused by host-specific species.
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| http://dx.doi.org/10.1016/j.pt.2024.09.008 | DOI Listing |
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Eimeria falciformis.
Trends Parasitol
December 2024
Intracellular Parasite Education and Research Labs (iPEARL), Department of Biological Sciences, Birla Institute of Science and Technology, Pilani (BITS-P), Hyderabad Campus, India; Department of Molecular Parasitology, Humboldt University, Berlin, Germany. Electronic address:
species (>1700) are widespread causative agents of coccidiosis in animals. Most species reproduce in the intestinal epithelial cells of distinct hosts. infects the cecum of for its asexual and sexual reproduction.
View Article and Find Full Text PDFStudy on the alleviative effect of on infection.
Infect Immun
July 2024
College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
Coccidia of the genus are specialized intracellular parasitic protozoa that cause severe coccidiosis when they infect their hosts. Animals infected with develop clinical symptoms, such as anorexia, diarrhea, and hematochezia, which can even cause death. Although the current preferred regimen for the treatment of coccidiosis is antibiotics, this treatment strategy is limited by the ban on antibiotics and the growing problem of drug resistance.
View Article and Find Full Text PDFEimeria falciformis extracellular vesicles differentially express host cell lncRNAs.
J Eukaryot Microbiol
March 2024
State Key Laboratory of Animal Disease Control and Prevention, Key Laboratory of Veterinary Parasitology of Gansu, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Article Synopsis
- Long noncoding RNAs (lncRNAs) play a crucial role in regulating host intestinal epithelial cells (IECs) during infections by the protozoan Eimeria falciformis.
- The study demonstrated that extracellular vesicles (EVs) from E. falciformis sporozoites can modify the expression of host RNA, including mRNA, circRNA, and lncRNA, by interacting with inactivated host cells.
- Notably, differentially expressed lncRNAs were linked to various immune signaling pathways and could serve as potential diagnostic markers for Eimeria infections.
Quantitative proteomic analysis of local and systemic extracellular vesicles during Eimeria falciformis infectious cycle in the host.
Parasit Vectors
September 2023
State Key Laboratory of Animal Disease Control and Prevention, Key Laboratory of Veterinary Parasitology of Gansu, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Background: Extracellular vesicles (EVs) are membranous structures that are formed during pathophysiology, host-parasite interactions and parasite motility. Typically, apicomplexan-infected host cells secrete EVs which traverse local and systemic strata of the host as the parasites develop.
Methods: Extracellular vesicles were isolated from the caecum and serum of Eimeria falciformis-infected mice during oocyst ingestion (0 h post-infection [0 hpi]), merozont stages 1 and 2 (68 and 116 hpi), oocyst shedding (7 days post-infection [7 dpi]) and host recovery (10 dpi) and subsequently characterized and profiled by tandem mass tag (TMT).
Tissue-resident, memory CD8 T cells are effective in clearing intestinal reinfection in mice.
Front Immunol
March 2023
National Key Laboratory of Veterinary Public Health Security, Beijing, China.
, a cousin of malarial parasites, causes coccidiosis that results in huge losses in the poultry industry. Although live coccidiosis vaccines have been developed and used widely for the successful control of the disease, the mechanism underlying protective immunity remains largely unknown. Using as a model parasite, we observed that tissue-resident memory CD8 T (Trm) cells accumulated in cecal lamina propria following infection in mice, especially after reinfection.
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