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Current Pharmacotherapy and Nutrition Therapy of Alcohol-Associated Liver Disease. | LitMetric

Current Pharmacotherapy and Nutrition Therapy of Alcohol-Associated Liver Disease.

Clin Liver Dis

Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY, USA; University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, KY, USA; Robley Rex Veterans Medical Center, Louisville, KY, USA; University of Louisville Hepatobiology & Toxicology Center, University of Louisville School of Medicine, Louisville, KY, USA. Electronic address:

Published: November 2024

AI Article Synopsis

  • * The main treatment for severe alcohol-associated hepatitis (AH) is corticosteroids, but not all patients respond effectively to this treatment.
  • * The article discusses key nutritional concepts for ALD and new insights into predicting how patients will respond to corticosteroids and their overall prognosis.

Article Abstract

Patients with alcohol-associated liver disease (ALD) consume large amounts of empty calories and are at risk for malnutrition. Malnutrition can present with micro- or macro-nutrient deficiencies. The standard-of-care drug treatment for severe alcohol-associated hepatitis (AH) is corticosteroids. While still in the standard treatment there are limitations in efficacy and certain patients do not respond to treatment (Lille score ≥.45). This article will focus on important concepts related to nutrition and ALD and on recent findings on predicting corticosteroid response and prognosis for AH patients.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529778PMC
http://dx.doi.org/10.1016/j.cld.2024.06.018DOI Listing

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