AI Article Synopsis
- - NRG Oncology's subcommittee gathered a diverse group of experts to tackle the issues faced in early phase clinical trials that combine radiation therapy with new treatment drugs.
- - The review highlights unique challenges in designing these trials, noting that they differ from traditional drug-drug combinations and are often neglected in planning.
- - The authors suggest potential solutions to overcome these barriers and present examples of clinical trial designs aimed at improving the assessment of these innovative drug-radiotherapy combinations.
Article Abstract
NRG Oncology's Developmental Therapeutics and Radiation Therapy Subcommittee assembled an interdisciplinary group of investigators to address barriers to successful early phase clinical trials of novel combination therapies involving radiation. This Policy Review elucidates some of the many challenges associated with study design for early phase trials combining radiotherapy with novel systemic agents, which are distinct from drug-drug combination development and are often overlooked. We also advocate for potential solutions that could mitigate or eliminate some of these barriers, providing examples of specific clinical trial designs that could help facilitate efficient and effective evaluation of novel drug-radiotherapy combinations.
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| http://dx.doi.org/10.1016/S1470-2045(24)00264-X | DOI Listing |
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