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Adolescent circadian rhythm disruption increases reward and risk-taking.
Front Neurosci
December 2024
Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Introduction: Circadian rhythm disturbances have long been associated with the development of psychiatric disorders, including mood and substance use disorders. Adolescence is a particularly vulnerable time for the onset of psychiatric disorders and for circadian rhythm and sleep disruptions. Preclinical studies have found that circadian rhythm disruption (CRD) impacts the brain and behavior, but this research is largely focused on adult disruptions.
View Article and Find Full Text PDFTopological Data Analysis of Ninjin'yoeito Effects Unraveling Complex Interconnections in Patients With Frailty: A Pilot Study.
Cureus
November 2024
Urogynecology, Yokosuka Urogynecology and Urology Clinic, Yokosuka, JPN.
Background Ninjin'yoeito (NYT), a traditional Japanese Kampo medicine, has shown potential in treating frailty and overactive bladder (OAB) symptoms. However, its effects are multifaceted and vary among individuals. This pilot study explored the use of topological data analysis (TDA) and natural language processing (NLP) to evaluate the effect of NYT on frailty in patients with OAB.
View Article and Find Full Text PDFOrthologs of and impact sleep in mice.
Sleep Adv
December 2024
Murine Phenotyping Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Model organisms such as are powerful tools to study the genetic basis of sleep. Previously, we identified the genes and using selective breeding for long and short sleep duration in an outbred population of . is a transcription factor that is part of the epidermal growth factor receptor signaling pathway, while is involved in proline and arginine metabolism.
View Article and Find Full Text PDFComparison analysis between standard polysomnographic data and in-ear-electroencephalography signals: a preliminary study.
Sleep Adv
November 2024
Department of Innovative Technologies, Institute of Digital Technologies for Personalized Healthcare (MeDiTech), University of Applied Sciences and Arts of Southern Switzerland, Lugano, Switzerland.
Study Objectives: Polysomnography (PSG) currently serves as the benchmark for evaluating sleep disorders. Its discomfort makes long-term monitoring unfeasible, leading to bias in sleep quality assessment. Hence, less invasive, cost-effective, and portable alternatives need to be explored.
View Article and Find Full Text PDFElevated cerebrospinal fluid biomarkers of neuroinflammation and neuronal damage in essential hypertension with secondary insomnia: Implications for Alzheimer's disease risk.
Brain Behav Immun
December 2024
Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China. Electronic address:
Essential hypertension (EH) with secondary insomnia is associated with increased risks of neuroinflammation, neuronal damage, and Alzheimer's disease (AD). However, its relationship with specific cerebrospinal fluid (CSF) biomarkers of neuronal damage and neuroinflammation remains unclear. This case-control study compared CSF biomarker levels across three groups: healthy controls (HC, n = 64), hypertension-controlled (HTN-C, n = 54), and hypertension-uncontrolled (HTN-U, n = 107) groups, all EH participants experiencing secondary insomnia.
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