Synthesis of -Alkyl Dithiocarbamates via Multicomponent Reaction of Cyclic Sulfonium Salts with CS and Amines.

J Org Chem

Key Laboratory of Comprehensive Utilization of Advantage Plants Resources of Southern Hunan, College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425100, China.

Published: October 2024

AI Article Synopsis

  • A new method has been discovered to create -alkyl dithiocarbamates using a three-component reaction involving sulfonium salts, carbon disulfide (CS), and amines.
  • This synthesis is efficient and does not require any catalysts or additives, allowing it to be performed under mild, open-air conditions.
  • The method shows promise for applications in fields like pharmaceutical and sulfur chemistry.

Article Abstract

A convenient and practical method for the synthesis of various -alkyl dithiocarbamates through three-component reaction of sulfonium salts, CS and amines has been developed. The reaction proceeds efficiently without any catalyst and additive under mild and open-air conditions, making it potential applications in pharmaceutical chemistry and sulfur chemistry.

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Source
http://dx.doi.org/10.1021/acs.joc.4c02063DOI Listing

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