AI Article Synopsis
- The study investigates the clinical usefulness of specific lung cancer-related autoantibodies in diagnosing non-small-cell lung cancer (NSCLC) and compares them with traditional cancer markers.
- The results showed that levels of the autoantibodies (CAGE, GBU4-5, MAGEA1, P53, PGP9.5, SOX2) were significantly higher in lung cancer patients than in other groups, indicating their potential as effective diagnostic tools (p < 0.01).
- The combined detection of these autoantibodies outperformed traditional markers like CEA, NSE, and CYFRA21-1, especially for adenocarcinoma and squamous cell carcinoma, suggesting a promising avenue for
Article Abstract
Evaluate the clinical value of lung-cancer-related autoantibodies (CAGE, GAGE7, GBU4-5, MAGEA1, P53, PGP9.5, SOX2) in auxiliary diagnosis of non-small-cell lung cancer (NSCLC). We detected the concentrations of above 7 antibodies and lung cancer markers (CEA, NSE, CYFRE21-1) and drew area under the receiver characteristic curve of 316 patients. The concentrations of CAGE, GBU4-5, MAGEA1, P53, PGP9.5 and SOX2 of significantly higher than other groups ( < 0.01). The sensitivity of different stages and pathological types of NSCLC consistent. Among them, the sensitivity of combined-detection in diagnosing adenocarcinoma and squamous cell carcinoma significantly better than CEA, NSE and CYFRA21-1. The combined detection has better efficacy in assisting the diagnosis of NSCLC and has certain clinical promotion and application value.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508994 | PMC |
| http://dx.doi.org/10.1080/17520363.2024.2404379 | DOI Listing |
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