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The internist as an expert in invasive ultrasound: Breaking barriers.
Med Clin (Barc)
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Unidad de Medicina Pleural y Ecografía Clínica, Servicio de Medicina Interna, Hospital Universitario Arnau de Vilanova, IRBLleida, Lleida, España. Electronic address:
Smart self-transforming nano-systems for overcoming biological barrier and enhancing tumor treatment efficacy.
J Control Release
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State Key Laboratory of Organic Electronics and Information Displays, Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, PR China. Electronic address:
Nanomedicines need to overcome multiple biological barriers in the body to reach the target area. However, traditional nanomedicines with constant physicochemical properties are not sufficient to meet the diverse and sometimes conflicting requirements during in vivo transport, making it difficult to penetrate various biological barriers, resulting in suboptimal drug delivery efficiency. Smart self-transforming nano-systems (SSTNs), capable of altering their own physicochemical properties (including size, charge, hydrophobicity, stiffness, morphology, etc.
View Article and Find Full Text PDFAn Oxidative Stress Nanoamplifier to Enhance the Efficacy of Cisplatin in Head and Neck Cancer.
Angew Chem Int Ed Engl
January 2025
NCNST: National Center for Nanoscience and Technology, CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, No 11, Zhongguancun Beiyitiao, Haidian, 100190, Beijing, CHINA.
Cisplatin (CP) is a first-line platinum-based drug used for the treatment of head and neck cancer. However, tumor cells can diminish the therapeutic effects of CP through the detoxification system mediated by glutathione (GSH) and the nucleotide excision repair (NER) pathway. Herein, we present a light-activable and pH-responsive oxidative stress nanoamplifier (FPLC@IR OSNA), comprising an amphiphilic compound (FPLC) with Fmoc-lysine acting as a connector between a nitroimidazole derivative and a pH-responsive cinnamaldehyde (CA) derivative, loaded with photosensitizer IR780.
View Article and Find Full Text PDFThink zebras: challenges and opportunities for treating rare cancers.
Trends Cancer
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Wellcome Sanger Institute, Hinxton, UK; Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro, Qro, Mexico. Electronic address:
The urinary eccDNA landscape in prostate cancer reveals associations with genome instability and vital roles in cancer progression.
J Adv Res
January 2025
Department of Urology, Center for Regeneration and Aging, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000 China. Electronic address:
Introduction: Extrachromosomal circular DNA (eccDNA) plays significant roles in cancer progression and prognosis. However, it remains unclear whether cell-free eccDNA, considered more stable than linear DNA, possesses cancer-specific genomic features. Furthermore, the biogenesis and function of eccDNAs are not yet fully understood.
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