AI Article Synopsis
- The study investigates the effectiveness and safety of a triple-combination therapy (high-dose corticosteroids, tacrolimus, and intravenous cyclophosphamide) for patients with anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5+ DM) who have interstitial lung disease (ILD).
- Despite hopes for positive outcomes, the therapy did not improve patient prognosis and was associated with higher mortality, particularly in high-risk patients with rapidly progressive ILD (RP-ILD).
- The findings indicate that this treatment may not be beneficial for MDA5+ DM patients, highlighting the need for further research to find safer and more effective therapies for this condition.
Article Abstract
Objectives: Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5+ DM) is frequently linked with interstitial lung disease (ILD), especially the rapidly progressive ILD (RP-ILD). We conduct this research to evaluate the efficacy and safety of triple-combination (triple-combo) therapy consisting of high-dose corticosteroids, tacrolimus and intravenous cyclophosphamide in treating MDA5+ DM patients with ILD.
Methods: A multicentre longitudinal cohort study involving 115 MDA5+ DM patients from the Nanjing Medical University Myositis Associated ILD (NMMI) cohort was conducted between January 2019 and November 2022. Patients were categorised into triple-combo and non-triple therapy groups, and their outcomes were assessed.
Results: Contrary to expectations, triple-combo therapy did not improve the prognosis for MDA5+ DM patients but was linked to increased mortality rates, especially among those at high risk for RP-ILD.
Conclusions: Our study suggests that triple-combo therapy might not be effective in improving prognosis in MDA5+ DM patients. Further research is needed to establish safer and more effective treatment modalities for this patient population.
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Source |
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| http://dx.doi.org/10.55563/clinexprheumatol/jmpuxa | DOI Listing |
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