AI Article Synopsis
- This study investigates the effects of low-frequency transcranial magnetic stimulation (LF-TMS) on gut microbiota in mice subjected to chronic unpredictable mild stress (CUMS).* -
- Mice underwent LF-TMS treatment for 28 days, which showed that CUMS significantly altered their gut microbiota composition and diversity, but LF-TMS treatment improved these microbiota indices compared to stressed mice.* -
- The findings suggest that LF-TMS can help mitigate stress-related behaviors in mice by regulating changes in their gut microbiota diversity and structure.*
Article Abstract
Objective: This paper presents a preliminary study on whether low-frequency transcranial magnetic stimulation (LF-TMS) can modulate the gut microbiota in mice with chronic unpredictable mild stress (CUMS).
Methods: Mice received LF-TMS (1 Hz, 20 mT) for 28 consecutive days under chronic unpredictable mild stress (CUMS). The composition of gut microbiota of stool samples were tested.
Results: CUMS caused significant changes in gut microbiotas, specifically in community diversity of gut microbiotas ( < .05). Compared with the stressed group mice, the Chao1 index ( < .05), Observed species index ( < .05), Faith's PD index ( < .05) and Shannon index ( < .05) of the LF-TMS treatment group were significantly increased. Furthermore, 1 Hz LF-TMS-treatment partially recovered chronic stress induced changes of microbiotas, such as the abundance of , .
Conclusion: These results manifested that LF-TMS treatment can improve the anhedonic behaviors caused by CUMS in mice, which are connected with regulating the related intestinal microbial community disturbance, including species diversity, structure of gut microbiota, and species composition.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443298 | PMC |
| http://dx.doi.org/10.5152/alphapsychiatry.2024.241561 | DOI Listing |
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