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Commentary: towards a national research infrastructure strategy for preclinical biological models in Australia.
Mamm Genome
January 2025
Phenomics Australia, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.
Research infrastructure is critical for advancing knowledge of health and disease, fostering innovation through world-class, cutting-edge facilities and technical expertise. Phenomics Australia is Australia's national research infrastructure provider responsible for accelerating advances in mammalian functional genomics and precision medicine through the development and delivery of services and expertise in engineered disease model production, phenotyping, and biobanking. These capabilities and resources are enabled by Australia's National Collaborative Research Infrastructure Strategy and primarily support health and medical research for significant healthcare and economic benefits.
View Article and Find Full Text PDFSeizing the opportunity to therapeutically address neuronal hyperexcitability in Alzheimer's disease.
J Alzheimers Dis
January 2025
Department of Pharmaceutics, University of Washington, Seattle, WA, USA.
Seizures in people with Alzheimer's disease are increasingly recognized to worsen disease burden and accelerate functional decline. Harnessing established antiseizure medicine discovery strategies in rodents with Alzheimer's disease associated risk genes represents a novel way to uncover disease modifying treatments that may benefit these Alzheimer's disease patients. This commentary discusses the recent evaluation by Dejakaisaya and colleagues to assess the antiseizure and disease-modifying potential of the repurposed cephalosporin antibiotic, ceftriaxone, in the Tg2576 mouse model.
View Article and Find Full Text PDFComment on: "The Utilization of the Accelerated Approval Pathway in Oncology: A Case Study of Pembrolizumab".
Drugs
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Azienda Ospedaliero Universitaria Sant'Andrea, Medical Oncology Unit, Sant'Andrea Hospital of Rome, Via di Grottarossa 1035-39, 00189, Rome, Italy.
Combination of ATRAP deletion and angiotensin II accelerates DKD progression, which may also accelerate DKD research.
Hypertens Res
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Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Commentary on: γ-enolase (ENO2) is methylated at the Nτ position of His-190 among enolase isozymes.
J Biochem
December 2024
Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.
Post-translational modifications play crucial roles in regulating protein function. Protein methylation, occurring at lysine, arginine, and histidine, has gained attention, particularly for histone methylation. However, the mechanism and significance of protein methylation at histidine remains poorly understood.
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