AI Article Synopsis
- - The study investigates the harmful effects of nicotine on male fertility and examines how selenium nanoparticles (SeNPs) and a new combination of SeNPs@vitamin C (SeNPs@VITC) can alleviate testicular toxicity caused by nicotine exposure.
- - Adult Wistar rats were divided into six treatment groups to assess various effects, with findings showing that nicotine led to decreased sperm quality and hormonal imbalances, while treatments with SeNPs and SeNPs@VITC improved these conditions.
- - Results indicated that the SeNPs@VITC nanocomposite was more effective than SeNPs alone in improving sperm count, reducing hormone levels, and enhancing overall testicular health, suggesting its potential
Article Abstract
Background: The tobacco epidemic signifies a major public health threat. Nicotine (NIC), a major active constituent in tobacco, impedes male fertility and semen quality. This work is implemented to explore the potential of selenium nanoparticles (SeNPs) and the newly fabricated SeNPs @vitamin C (SeNPs@VITC) nanocomposite in mitigating testicular toxicity induced by NIC.
Materials And Methods: The six groups of 48 adult Wistar rats were designed as follows: the control group injected intraperitoneally with normal saline, the SeNPs group treated orally with 2 mg/kg of SeNPs, the SeNPs@VITC nanocomposite group treated orally with 2 mg/kg of SeNPs@VITC nanocomposite, the NIC group injected intraperitoneally with 1.25 mL/kg of NIC, the NIC+ SeNPs group received SeNPs plus NIC, and the NIC+ SeNPs@VITC nanocomposite group received SeNPs@VITC nanocomposite plus NIC. Treatments were administered over a 28-day period.
Results: NIC treatment significantly caused poor sperm quality, decreased serum testosterone, increased follicle-stimulating hormone (FSH), luteinizing hormone (LH) concentrations, reduced hemoglobin levels, leukocytosis, disrupted testicular oxidant/antioxidant balance, and disorganized testicular structure. The construction of the novel SeNPs@VITC nanocomposite, compared to NIC plus SeNPs alone, demonstrated a more potent ameliorative effect on NIC-induced reproductive toxicity in adult rats. The SeNPs@VITC nanocomposite significantly increased sperm count, reduced the percentage of sperm head abnormalities, lowered both serum FSH and LH concentrations, and improved the hemoglobin response.
Conclusions: Both SeNPs and SeNPs@VITC nanocomposite alleviated the testicular toxicity induced by NIC, but the SeNPs@VITC nanocomposite exhibited superior efficacy. The SeNPs@VITC nanocomposite could be employed to advance enhanced therapeutic strategies for addressing male infertility.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442148 | PMC |
| http://dx.doi.org/10.1093/toxres/tfae154 | DOI Listing |
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