Investigating the Relationship of , , and Polymorphisms in the Promoter of and Inflammatory Genes with Prostate Cancer in an Iranian Population.

Introduction: Genetic and environmental factors are involved in prostate cancer. The current study was conducted to study the relationship between , , and polymorphisms in the promoter of and inflammatory genes with prostate cancer.

Methods: As a genetic association study with a case-control design, the genomes of people living in Khorasan, Iran, were compared in two groups of cases and controls. The genotype of the polymorphism present in the gene promoter was investigated by the PCR-RFLP method. PCR-SSP was used to study the genotype of and polymorphisms present in the gene promoter. Odds ratio (OR) and 95% confidence interval (CI) were reported.

Results: One mutant allele in polymorphism (AG) increased the chance of cancer (OR = 4.902, 95% CI = 2.70-8.87) and two mutant alleles (GG) increased more (OR = 7.174, 95% CI = 2.48-20.68). One mutant allele in polymorphism (CG) increased the chance of cancer (OR = 5.583, 95% CI = 3.04-10.22) and two mutant alleles (CC) increased more (OR = 9.571, 95% CI = 3.10-29.46). One mutant allele in polymorphism (CA) increased the chance of cancer (OR = 5.359, 95% CI = 2.95-9.70) and two mutant alleles (AA) increased more (OR = 7.083, 95% CI = 2.61-19.15) ( < 0.001).

Conclusion: According to the results, the mutant alleles in polymorphisms , , and alleles were associated with an increased chance of prostate cancer in this population.