AI Article Synopsis

  • MCRs (multicomponent reactions) have been utilized since their discovery in 1850 and are valued for their efficiency in creating diverse and complex organic molecules.
  • These reactions, including Ugi, Passerini, Biginelli, and Hantzsch, play a crucial role in medicinal chemistry and industrial applications while promoting sustainable practices.
  • Advantages of MCRs include atom economy, recyclable catalysts, reduced waste, and simplification of the synthesis process by combining multiple steps into one.

Article Abstract

Since Strecker's discovery of multicomponent reactions (MCRs) in 1850, the strategy of applying an MCR approach has been in use for over a century. Due to their ability to quickly develop molecular diversity and structural complexity of interest, MCRs are considered an efficient approach in organic synthesis. Although MCRs such as the Ugi, Passerini, Biginelli, and Hantzsch reactions are widely studied, this review emphasizes the significance of selective MCRs to elegantly produce organic compounds of potential use in medicinal chemistry and industrial and material science applications, as well as the use of the MCR approach to sustainable methods. During synthesis, MCRs provide advantages such as atom economy, recyclable catalysts, moderate conditions, preventing waste, and avoiding solvent use. MCRs also reduce the number of sequential multiple reactions to one step.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445040PMC
http://dx.doi.org/10.3389/fchem.2024.1469677DOI Listing

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