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Metabolic interactions shape emergent biofilm structures in a conceptual model of gut mucosal bacterial communities. | LitMetric

Metabolic interactions shape emergent biofilm structures in a conceptual model of gut mucosal bacterial communities.

NPJ Biofilms Microbiomes

Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, CA, 94720, USA.

Published: October 2024

AI Article Synopsis

Article Abstract

The gut microbiome plays a major role in human health; however, little is known about the structural arrangement of microbes and factors governing their distribution. In this work, we present an in silico agent-based model (ABM) to conceptually simulate the dynamics of gut mucosal bacterial communities. We explored how various types of metabolic interactions, including competition, neutralism, commensalism, and mutualism, affect community structure, through nutrient consumption and metabolite exchange. Results showed that, across scenarios with different initial species abundances, cross-feeding promotes species coexistence. Morphologically, competition and neutralism resulted in segregation, while mutualism and commensalism fostered high intermixing. In addition, cooperative relations resulted in community properties with little sensitivity to the selective uptake of metabolites produced by the host. Moreover, metabolic interactions strongly influenced colonization success following the invasion of newcomer species. These results provide important insights into the utility of ABM in deciphering complex microbiome patterns.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447261PMC
http://dx.doi.org/10.1038/s41522-024-00572-yDOI Listing

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