A distinct model of neutral evolution of rare cancer mutations is described and contrasted with models relying on the infinite sites approximation (that a specific mutation arises in only one cell at any instant). An explosion of genetic diversity is predicted at clinical cell numbers and may explain the progressive refractoriness of cancers during a clinical course. The widely used infinite sites assumption may not be applicable for clinical cancers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447017 | PMC |
| http://dx.doi.org/10.1038/s41540-024-00436-3 | DOI Listing |
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