AI Article Synopsis
- Lifelong maintenance of blood cell production relies on the proper functioning of hematopoietic stem cells, which are regulated by thrombopoietin, a key cytokine.
- Thrombopoietin not only helps maintain these stem cells but also plays a crucial role in the development of megakaryocytes, the cells responsible for producing platelets.
- Research using thrombopoietin gene-deficient mice has revealed how thrombopoietin receptor agonists aid in sustaining stem cell populations and their differentiation, highlighting their importance in treating bone marrow failure disorders like aplastic anemia.
Article Abstract
Sustaining lifelong hematopoiesis requires maintenance, proliferation, and differentiation of hematopoietic stem cells. Thrombopoietin is a cytokine essential for regulation of hematopoietic stem cells as well as differentiation and maturation of megakaryocytes required for platelet production. Due to these properties, thrombopoietin agonists have been used to treat bone marrow failure syndromes such as aplastic anemia. Through analysis of thrombopoietin gene-deficient mice, my colleagues and I have demonstrated the mechanism of action of thrombopoietin receptor agonists in hematopoietic stem cell maintenance and differentiation. This review focuses on governance of homeostasis in the hematopoietic system by thrombopoietin signaling.
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| http://dx.doi.org/10.11406/rinketsu.65.872 | DOI Listing |
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