AI Article Synopsis
- Reciprocal communication between the brain and immune system is vital for maintaining brain function throughout life, with immune cells playing a crucial role in this interaction.
- Immune exhaustion and senescence may accelerate neurodegenerative diseases, indicating that a weakened peripheral immune system contributes to the progression of these conditions.
- Strategies to enhance peripheral immunity, such as blocking inhibitory checkpoint molecules, could harness reparative immune cells to help the brain combat neurodegeneration effectively.
Article Abstract
Reciprocal communication between the brain and the immune system is essential for maintaining lifelong brain function. This interaction is mediated, at least in part, by immune cells recruited from both the circulation and niches at the borders of the brain. Here, we describe how immune exhaustion and senescence, even if not primary causative factors, can accelerate neurodegenerative diseases. We emphasize the role of a compromised peripheral immune system in driving neurodegeneration and discuss strategies for harnessing peripheral immunity to effectively treat neurodegenerative diseases, including the underlying mechanisms and opportunities for clinical translation. Specifically, we highlight the potential of boosting the immune system by blocking inhibitory checkpoint molecules to harness reparative immune cells in helping the brain to fight against neurodegeneration.
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| http://dx.doi.org/10.1016/j.it.2024.08.002 | DOI Listing |
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