AI Article Synopsis
- Emerging research suggests a connection between type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), highlighting brain insulin resistance as a crucial element.
- A study by Lanzillotta et al. shows that lower levels of biliverdin reductase-A (BVR-A) negatively affect the phosphorylation of glycogen synthase kinase 3β (GSK3β).
- This impairment leads to mitochondrial dysfunction, worsening brain insulin resistance and contributing to the advancement of both T2DM and AD.
Article Abstract
Emerging evidence links type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), with brain insulin resistance (BIR) as a key factor. In a recent study, Lanzillotta et al. reveal that reduced biliverdin reductase-A (BVR-A) impairs glycogen synthase kinase 3β (GSK3β) phosphorylation, causing mitochondrial dysfunction and exacerbating brain insulin resistance in the progression of both T2DM and AD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tibs.2024.09.004 | DOI Listing |
Publication Analysis
Top Keywords
brain insulin
12
insulin resistance
12
bridging brain
4
resistance alzheimer's
4
alzheimer's pathogenesis
4
pathogenesis emerging
4
emerging evidence
4
evidence links
4
links type
4
type diabetes
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!