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Haemodynamic measurements during hip hemiarthroplasty surgery for hip fracture.
Bone Joint J
January 2025
Oxford Trauma and Emergency Care, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Kadoorie Centre, University of Oxford, Oxford, UK.
Aims: There is compelling evidence for the use of cemented hip hemiarthroplasty for displaced intracapsular hip fractures; however, the risks of cement are well reported and in rare cases may be associated with haemodynamic collapse. It is therefore important to improve our understanding of haemodynamic instability, intraoperative monitoring, and strategies to reduce the risk to patients.
Methods: We measured arterial blood pressure using the LiDCO Continuous Non-invasive Arterial Pressure (CNAP) finger cuff during surgery in patients enrolled in the WHiTE 5 trial randomized to cemented or modern uncemented hip hemiarthroplasty at a single recruiting site.
Azathioprine/hydroxyurea preconditioning prior to nonmyeloablative matched sibling donor hematopoietic stem cell transplantation in adults with sickle cell disease: A prospective observational cohort study.
Am J Hematol
August 2024
Department of Hematology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
Nonmyeloablative, matched sibling donor hematopoietic stem cell transplantation with alemtuzumab/total body irradiation (TBI) conditioning is a curative therapy with low toxicity for adults with sickle cell disease (SCD). However, relatively low donor chimerism levels and graft rejection remain important challenges. We hypothesized that adding azathioprine/hydroxyurea preconditioning will improve donor chimerism levels and reduce graft failure rate.
View Article and Find Full Text PDFAdherence to vascular care guidelines for emergency revascularization of chronic limb-threatening ischemia.
J Vasc Surg Cases Innov Tech
December 2023
Department of Vascular Surgery, Cambridge University Hospitals, Queens' College, Cambridge, UK.
Article Synopsis
- The study evaluated the impact of the CQUIN pay-for-performance program on timely revascularization for chronic limb-threatening ischemia (CLTI) in a hospital setting.
- The introduction of financial incentives led to an increase in patients receiving revascularization within 5 days, rising from 41.2% to 58.8%.
- Improvements were noted in some care pathway metrics, although no significant changes were found in overall patient outcomes related to complications.
Ocular Inflammatory Events Following COVID-19 Vaccination in the Paediatric Population: A Multinational Case Series.
Ocul Immunol Inflamm
September 2024
Rheumatology Department, Great Ormond Street Hospital for Children, London, UK.
Background: Ocular inflammatory events following COVID-19 vaccination have been reported in the adult population.
Methods: Multinational case series of patients under the age of 18 diagnosed with ocular inflammatory events within 28 days of COVID-19 vaccination.
Results: Twenty individuals were included.
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