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Long noncoding RNA FAM111A-DT promotes aggressiveness of papillary thyroid cancer via activating NF-κB signaling.
J Endocrinol Invest
January 2025
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Purpose: Long noncoding RNAs (lncRNAs) play crucial regulatory roles in the tumorigenesis and progression of various cancers. However, the functional roles of lncRNAs in papillary thyroid cancer (PTC) remain unclear. In this study, we investigated the functional role of the lncRNA FAM111A-DT in PTC progression and the underlying mechanisms.
View Article and Find Full Text PDFListening to placebos: the contested lessons of antidepressants debates.
Hist Philos Life Sci
January 2025
University of Buenos Aires, Buenos Aires, Argentina.
The goal of this paper is to explore a set of epistemological and ontological issues regarding the historical and philosophical role of placebos in the contested history of antidepressants. Starting from an account of the dual nature of the placebo as both an epistemic and a therapeutic tool, and against the background of the heated debates on the efficacy of second-generation antidepressants, I propose two related arguments. First, I argue that placebos as controls played a crucial but paradoxical role in the rise of so-called evidence-based approaches to depression.
View Article and Find Full Text PDFpmiRScan: a LightGBM based method for prediction of animal pre-miRNAs.
Funct Integr Genomics
January 2025
Computational Structural Biology Lab, Department of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, 721302, India.
MicroRNAs (miRNA) are categorized as short endogenous non-coding RNAs, which have a significant role in post-transcriptional gene regulation. Identifying new animal precursor miRNA (pre-miRNA) and miRNA is crucial to understand the role of miRNAs in various biological processes including the development of diseases. The present study focuses on the development of a Light Gradient Boost (LGB) based method for the classification of animal pre-miRNAs using various sequence and secondary structural features.
View Article and Find Full Text PDFABA-mediated regulation of PME12 influences stomatal density, pore aperture, and heat stress response in Arabidopsis thaliana.
Planta
January 2025
Institute of Plant Biology, National Taiwan University, Taipei, Taiwan.
PME12-mutated plants displayed altered stomatal characteristics and susceptibility to ABA-induced closure. Despite changes in PME activity, the mutant exhibited enhanced thermotolerance. These findings suggest a complex interplay between pectin methylesterification, ABA response, and stomatal function, contributing to plant adaptation to heat stress.
View Article and Find Full Text PDFNormative values of grip and pinch strength and their predictor factors: PERSIAN cohort study of healthcare staff.
Int Orthop
January 2025
Orthopedics Research Center, Ghaem Hospital, Mashhad University of Medical Science, Mashhad, Iran.
Purpose: The present study aims to provide normative values for Hand Grip Strength (HGS) and Hand Pinch Strength of healthcare staff and evaluate key body anthropometric predictors of these strengths.
Methods: This cross sectional study was conducted on 2,337 healthcare staff. HGS and pinch strength were assessed for both hands using a hydraulic hand dynamometer and pinch gauge.
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