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Prospective Randomized Study on Switching Triple Inhaler Therapy in COPD from Multiple Inhaler Devices to a Single Inhaler Device in a Chinese Population.
Chronic Obstr Pulm Dis
December 2024
Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Background: Triple therapy with inhaled corticosteroids and dual bronchodilator was recommended in chronic obstructive pulmonary disease (COPD) patients who had exacerbations and eosinophilia. It can be administered by single inhaler (SITT) or multiple inhaler (MITT). There was lack of evidence of the benefits of SITT over MITT in Chinese population, especially on switching from existing MITT to SITT.
View Article and Find Full Text PDFRun-in periods and treatment outcomes in asthma trials: A narrative review.
Contemp Clin Trials Commun
December 2024
GSK, Collegeville, PA, USA.
Background: The run-in period is an important element of randomized controlled trials, and is often used in respiratory disease trials. The design of the run-in period can greatly impact results and data interpretation, and as such should be designed carefully.
Methods: In this review, we describe the design of run-in periods across six phase 3A trials of triple therapy in asthma, and discuss how differences in run-in period design (specifically the duration, treatment, and reporting of run-in results) may have the potential to alter the interpretation of study outcomes.
Comparative adherence and persistence of single-inhaler and multiple-inhaler triple therapies among patients with chronic obstructive pulmonary disease in Japan: a retrospective cohort study.
BMJ Open
December 2024
Value Evidence and Outcomes, R&D Global Medical, GlaxoSmithKline, London, UK
Objectives: To evaluate and compare medication adherence and persistence for patients newly initiating single-inhaler triple therapy (SITT) and multiple-inhaler triple therapy (MITT) for chronic obstructive pulmonary disease (COPD) in Japan.
Design: Retrospective, new-user, active comparator, observational cohort study using inverse probability of treatment weighting.
Setting: Health insurance claims data from the Medical Data Vision Co.
Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity.
Elife
December 2024
Trinity Translational Medicine Institute, St James's Hospital, Trinity College Dublin, The University of Dublin, Dublin, Ireland.
Article Synopsis
- - Airway macrophages (AM) are key immune cells in the lungs that help protect against infections, making them important for targeted therapies aimed at enhancing immune responses.
- - The study investigates how different types of macrophages respond to signaling molecules (IFN-γ and IL-4) that represent immune responses in the lungs, finding that AM rely heavily on glycolysis for their functions, especially in cytokine production.
- - Results show that AM exhibit unique metabolic responses and functional plasticity compared to monocyte-derived macrophages (MDM), suggesting that AM could be effective targets for new inhaled treatments for lung diseases.
Cross-Generational Impact of Maternal Exposure to Low Level of PM2.5 on Kidney Health.
Am J Nephrol
November 2024
Kolling Institute of Medical Research, Royal North Shore Hospital, The University of Sydney, Sydney, New South Wales, Australia.
Introduction: Inhaled fine and ultrafine particulate matter may affect organs other than the lung, including the kidney. Recent studies have consistently shown the possibility of air pollution in highly polluted countries to be nephrotoxic. However, in countries like Australia, where air quality generally adheres to or remains below the WHO standards, the subtle yet consequential impacts of chronic exposure to seemingly safe levels of traffic PM2.
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